Frank Madeo Selected Research

Cognitive Dysfunction

6/2022	Correction: Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial.
1/2022	Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
1/2021	Dietary spermidine improves cognitive function.
1/2019	Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial.
12/2018	The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
1/2018	Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.

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Frank Madeo Research Topics

Disease

24	Neoplasms (Cancer) 07/2023 - 01/2005
12	Starvation 01/2021 - 05/2006
10	Obesity 01/2023 - 07/2010
8	Necrosis 01/2018 - 07/2006
6	Cardiovascular Diseases (Cardiovascular Disease) 01/2023 - 12/2016
6	Cognitive Dysfunction 06/2022 - 01/2018
5	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 10/2014
5	Inflammation (Inflammations) 01/2022 - 08/2011
4	Heart Failure 10/2022 - 12/2016
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 09/2006
4	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2017 - 05/2007
3	Myocardial Infarction 01/2023 - 07/2010
3	Hypertension (High Blood Pressure) 10/2021 - 12/2016
3	Malnutrition (Nutritional Deficiencies) 01/2021 - 01/2015
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 08/2012
3	Parkinson Disease (Parkinson's Disease) 11/2013 - 03/2008
2	Insulin Resistance 01/2023 - 01/2023
2	Stroke (Strokes) 01/2023 - 01/2023
2	Cardiotoxicity 01/2023 - 01/2020
2	Weight Gain 01/2021 - 10/2019
2	Dementia (Dementias) 12/2018 - 06/2011
2	Metabolic Diseases (Metabolic Disease) 11/2017 - 01/2014
2	Lung Neoplasms (Lung Cancer) 11/2016 - 08/2012
1	Type 2 Diabetes Mellitus (MODY) 01/2023
1	Frailty 01/2023
1	Fatty Liver 01/2023
1	Infections 01/2023
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2021
1	COVID-19 01/2021
1	Overnutrition 01/2021
1	Alopecia (Baldness) 01/2021
1	Glucose Intolerance 10/2020
1	Hepatolenticular Degeneration (Wilson's Disease) 10/2020
1	Confusion (Bewilderment) 01/2020
1	Diabetic Cardiomyopathies 01/2020
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2020
1	Cardiac Arrhythmias (Arrythmia) 01/2020
1	Weight Loss (Weight Reduction) 10/2019
1	Hyperphagia (Overeating) 09/2019

Drug/Important Bio-Agent (IBA)

20	SpermidineIBA 07/2023 - 11/2009
10	PolyaminesIBA 07/2023 - 11/2009
9	Proteins (Proteins, Gene)FDA Link 10/2019 - 05/2006
6	5-methoxy-methylindoleacetic acid (DBI)IBA 01/2023 - 09/2019
5	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2019
4	Diazepam Binding InhibitorIBA 01/2023 - 10/2019
3	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 01/2021
3	EnzymesIBA 01/2023 - 11/2011
3	Amyloid beta-PeptidesIBA 01/2022 - 03/2010
3	LeptinIBA 10/2020 - 09/2019
3	Fatty Acids (Saturated Fatty Acids)IBA 10/2019 - 07/2010
3	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2017 - 07/2006
3	endonuclease GIBA 11/2013 - 05/2007
2	Acyl Coenzyme A (Acyl CoA)IBA 01/2023 - 01/2021
2	Carrier Proteins (Binding Protein)IBA 01/2023 - 01/2021
2	Trientine (Trien)FDA Link 10/2020 - 01/2020
2	Peptides (Polypeptides)IBA 01/2019 - 10/2014
2	Acetyl Coenzyme A (Acetyl-CoA)IBA 01/2019 - 07/2014
2	Amyloid (Amyloid Fibrils)IBA 01/2019 - 10/2014
2	ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)IBA 01/2019 - 11/2016
2	Plant ExtractsIBA 12/2018 - 01/2018
2	SaltsIBA 04/2017 - 12/2016
2	CarcinogensIBA 10/2016 - 09/2012
2	Adenosine Triphosphate (ATP)IBA 10/2016 - 06/2008
2	SynucleinsIBA 11/2013 - 10/2010
2	CalreticulinIBA 09/2012 - 02/2009
2	DNA (Deoxyribonucleic Acid)IBA 09/2012 - 09/2012
2	Cisplatin (Platino)FDA LinkGeneric 09/2012 - 08/2012
2	N-acetylsphingosineIBA 09/2012 - 11/2011
2	Sirolimus (Rapamycin)FDA Link 03/2012 - 06/2008
2	Amino Acids FDA Link 03/2012 - 02/2009
2	CeramidesIBA 11/2011 - 02/2010
2	LipidsIBA 08/2011 - 07/2010
2	polyglutamineIBA 03/2010 - 09/2006
1	Insulin (Novolin)FDA Link 01/2023
1	harmolIBA 01/2023
1	Monoclonal AntibodiesIBA 01/2023
1	gamma-Aminobutyric Acid (GABA)IBA 01/2023
1	ImmunosorbentsIBA 01/2023
1	AnthracyclinesIBA 01/2023
1	Cyclin-Dependent Kinase Inhibitor p16IBA 01/2023
1	Autophagy-Related Protein-1 HomologIBA 10/2022
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 10/2022
1	Niacinamide (Nicotinamide)FDA LinkGeneric 10/2021
1	anthranilic acid (anthranilate)IBA 01/2021
1	SpermineIBA 01/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021
1	KynurenineIBA 01/2021
1	Tryptophan (L-Tryptophan)FDA Link 01/2021
1	CytokinesIBA 01/2021
1	N',N''-diacetylspermineIBA 01/2021
1	CopperIBA 10/2020
1	Chelating AgentsIBA 10/2020
1	Sucrose (Saccharose)IBA 10/2020
1	CaspasesIBA 01/2020
1	GhrelinIBA 09/2019

Therapy/Procedure

5	Drug Therapy (Chemotherapy) 01/2021 - 10/2016
5	Caloric Restriction 01/2019 - 01/2010
3	Therapeutics 01/2015 - 01/2005
1	Aftercare (After-Treatment) 01/2023